Research Projects of the Laboratory Members



LABORATORY OF PROTEOMICS

NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE, LISBON, PORTUGAL 








Mission:

The ultimate mission of the laboratory is to provide the society with new diagnostic, prognostic and/or follow-up tools based on proteomics allowing clinicians to truly tailor therapy.

Main Research Interest

•          Translational proteomics: biomarker discovery and validation for Chronic Lung Diseases (e.g., Cystic Fibrosis, Asthma, COPD, Obstructive Sleep Apnea). 

•          Pharmacoproteomics (e.g., global drug profiling) and Toxicoproteomics (e.g., molecular effects of environmental tobacco smoke exposure (TSE)).

•          Development of proteomics-based technologies for biomarker discovery, validation and translation [e.g., mass spectrometric immunoassay – MSIA)

Research Support Services / Collaborations

We have established a complete pipeline for analysis of clinical samples (plasma, blood cells, tissue) using state of art proteomics-based technologies (2-DIGE, LC/MS/MS, MSIA) and Mass Spectrometry (MS) instruments (MALDI-TOFTOF, Orbitrap) which supports all quantitative proteomics-based technologies. This pipeline is designed to disease biomarker discovery (clinical proteomics) or global drug / TSE profiling (pharmacoproteomics/toxicoproteomics) but it can be used in any proteomics-based project. 


Contact Persons

PENQUE, Deborah

Head of the Laboratory
deborah.penque@insa.min-saude.pt

www.insarj.pt
Telephone: +351 217508137
Fax: +351 217526410